U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Renal sclerosis with hypertension

MedGen UID:
538735
•Concept ID:
C0264657
•
Disease or Syndrome
Synonym: Hypertensive nephrosclerosis
SNOMED CT: Renal sclerosis with hypertension (14973001); Hypertensive nephrosclerosis (473392002)

Professional guidelines

PubMed

Clinical Treatment Options in Scleroderma: Recommendations and Comprehensive Review.
Zhao M, Wu J, Wu H, Sawalha AH, Lu Q
Clin Rev Allergy Immunol 2022 Apr;62(2):273-291. Epub 2021 Jan 15 doi: 10.1007/s12016-020-08831-4. PMID: 33449302
Update of EULAR recommendations for the treatment of systemic sclerosis.
Kowal-Bielecka O, Fransen J, Avouac J, Becker M, Kulak A, Allanore Y, Distler O, Clements P, Cutolo M, Czirjak L, Damjanov N, Del Galdo F, Denton CP, Distler JHW, Foeldvari I, Figelstone K, Frerix M, Furst DE, Guiducci S, Hunzelmann N, Khanna D, Matucci-Cerinic M, Herrick AL, van den Hoogen F, van Laar JM, Riemekasten G, Silver R, Smith V, Sulli A, Tarner I, Tyndall A, Welling J, Wigley F, Valentini G, Walker UA, Zulian F, Müller-Ladner U; EUSTAR Coauthors
Ann Rheum Dis 2017 Aug;76(8):1327-1339. Epub 2016 Nov 9 doi: 10.1136/annrheumdis-2016-209909. PMID: 27941129
Management of systemic sclerosis.
Lim IG, Schrieber L
Isr Med Assoc J 2002 Nov;4(11 Suppl):953-7. PMID: 12455189

Recent clinical studies

Etiology

Renal Disease and Systemic Sclerosis: an Update on Scleroderma Renal Crisis.
Cole A, Ong VH, Denton CP
Clin Rev Allergy Immunol 2023 Jun;64(3):378-391. Epub 2022 Jun 1 doi: 10.1007/s12016-022-08945-x. PMID: 35648373Free PMC Article
Hypertension and kidney disease progression.
Rigo D, Orias M
Clin Nephrol 2020 Supplement-Jan;93(1):103-107. doi: 10.5414/CNP92S118. PMID: 31549630
Update of EULAR recommendations for the treatment of systemic sclerosis.
Kowal-Bielecka O, Fransen J, Avouac J, Becker M, Kulak A, Allanore Y, Distler O, Clements P, Cutolo M, Czirjak L, Damjanov N, Del Galdo F, Denton CP, Distler JHW, Foeldvari I, Figelstone K, Frerix M, Furst DE, Guiducci S, Hunzelmann N, Khanna D, Matucci-Cerinic M, Herrick AL, van den Hoogen F, van Laar JM, Riemekasten G, Silver R, Smith V, Sulli A, Tarner I, Tyndall A, Welling J, Wigley F, Valentini G, Walker UA, Zulian F, Müller-Ladner U; EUSTAR Coauthors
Ann Rheum Dis 2017 Aug;76(8):1327-1339. Epub 2016 Nov 9 doi: 10.1136/annrheumdis-2016-209909. PMID: 27941129
Hypertension and kidneys: unraveling complex molecular mechanisms underlying hypertensive renal damage.
Mennuni S, Rubattu S, Pierelli G, Tocci G, Fofi C, Volpe M
J Hum Hypertens 2014 Feb;28(2):74-9. Epub 2013 Jun 27 doi: 10.1038/jhh.2013.55. PMID: 23803592
Risk factors associated with hypertensive nephrosclerosis.
Bleyer AJ, Appel RG
Nephron 1999;82(3):193-8. doi: 10.1159/000045402. PMID: 10395990

Diagnosis

Renal involvement in systemic sclerosis.
Scheen M, Dominati A, Olivier V, Nasr S, De Seigneux S, Mekinian A, Issa N, Haidar F
Autoimmun Rev 2023 Jun;22(6):103330. Epub 2023 Apr 7 doi: 10.1016/j.autrev.2023.103330. PMID: 37031831
Renal Disease and Systemic Sclerosis: an Update on Scleroderma Renal Crisis.
Cole A, Ong VH, Denton CP
Clin Rev Allergy Immunol 2023 Jun;64(3):378-391. Epub 2022 Jun 1 doi: 10.1007/s12016-022-08945-x. PMID: 35648373Free PMC Article
Hypertension and kidney disease progression.
Rigo D, Orias M
Clin Nephrol 2020 Supplement-Jan;93(1):103-107. doi: 10.5414/CNP92S118. PMID: 31549630
Systemic sclerosis.
Denton CP, Khanna D
Lancet 2017 Oct 7;390(10103):1685-1699. Epub 2017 Apr 13 doi: 10.1016/S0140-6736(17)30933-9. PMID: 28413064
Structural and Functional Changes With the Aging Kidney.
Denic A, Glassock RJ, Rule AD
Adv Chronic Kidney Dis 2016 Jan;23(1):19-28. doi: 10.1053/j.ackd.2015.08.004. PMID: 26709059Free PMC Article

Therapy

Renal Disease and Systemic Sclerosis: an Update on Scleroderma Renal Crisis.
Cole A, Ong VH, Denton CP
Clin Rev Allergy Immunol 2023 Jun;64(3):378-391. Epub 2022 Jun 1 doi: 10.1007/s12016-022-08945-x. PMID: 35648373Free PMC Article
Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors.
DeFronzo RA, Reeves WB, Awad AS
Nat Rev Nephrol 2021 May;17(5):319-334. Epub 2021 Feb 5 doi: 10.1038/s41581-021-00393-8. PMID: 33547417
Update of EULAR recommendations for the treatment of systemic sclerosis.
Kowal-Bielecka O, Fransen J, Avouac J, Becker M, Kulak A, Allanore Y, Distler O, Clements P, Cutolo M, Czirjak L, Damjanov N, Del Galdo F, Denton CP, Distler JHW, Foeldvari I, Figelstone K, Frerix M, Furst DE, Guiducci S, Hunzelmann N, Khanna D, Matucci-Cerinic M, Herrick AL, van den Hoogen F, van Laar JM, Riemekasten G, Silver R, Smith V, Sulli A, Tarner I, Tyndall A, Welling J, Wigley F, Valentini G, Walker UA, Zulian F, Müller-Ladner U; EUSTAR Coauthors
Ann Rheum Dis 2017 Aug;76(8):1327-1339. Epub 2016 Nov 9 doi: 10.1136/annrheumdis-2016-209909. PMID: 27941129
Scleroderma Renal Crisis.
Guillevin L, Mouthon L
Rheum Dis Clin North Am 2015 Aug;41(3):475-88. Epub 2015 May 26 doi: 10.1016/j.rdc.2015.04.008. PMID: 26210130
Systemic and localized scleroderma.
Chung L, Lin J, Furst DE, Fiorentino D
Clin Dermatol 2006 Sep-Oct;24(5):374-92. doi: 10.1016/j.clindermatol.2006.07.004. PMID: 16966019

Prognosis

Mesangial Injury and Capillary Ballooning Precede Podocyte Damage in Nephrosclerosis.
Kriz W, Wiech T, Gröne HJ
Am J Pathol 2022 Dec;192(12):1670-1682. Epub 2022 Sep 21 doi: 10.1016/j.ajpath.2022.08.007. PMID: 36150506
The ageing kidney: Molecular mechanisms and clinical implications.
Fang Y, Gong AY, Haller ST, Dworkin LD, Liu Z, Gong R
Ageing Res Rev 2020 Nov;63:101151. Epub 2020 Aug 22 doi: 10.1016/j.arr.2020.101151. PMID: 32835891Free PMC Article
Hypertension and kidneys: unraveling complex molecular mechanisms underlying hypertensive renal damage.
Mennuni S, Rubattu S, Pierelli G, Tocci G, Fofi C, Volpe M
J Hum Hypertens 2014 Feb;28(2):74-9. Epub 2013 Jun 27 doi: 10.1038/jhh.2013.55. PMID: 23803592
Nephroangiosclerosis and its pharmacological approach.
Cianci R, Barbano B, Martina P, Gigante A, Polidori L, Lai S, Ascoli G, De Francesco I, Di Donato D, Fuiano G, Zuccalà A
Curr Vasc Pharmacol 2011 Mar;9(2):238-43. doi: 10.2174/157016111794519309. PMID: 20507278
Renal endpoints in hypertension trials.
Christiansen H, Segura J, Ruilope LM
Clin Exp Hypertens 2004 Oct-Nov;26(7-8):721-6. doi: 10.1081/ceh-200032109. PMID: 15702626

Clinical prediction guides

Renal involvement in systemic sclerosis.
Scheen M, Dominati A, Olivier V, Nasr S, De Seigneux S, Mekinian A, Issa N, Haidar F
Autoimmun Rev 2023 Jun;22(6):103330. Epub 2023 Apr 7 doi: 10.1016/j.autrev.2023.103330. PMID: 37031831
Mesangial Injury and Capillary Ballooning Precede Podocyte Damage in Nephrosclerosis.
Kriz W, Wiech T, Gröne HJ
Am J Pathol 2022 Dec;192(12):1670-1682. Epub 2022 Sep 21 doi: 10.1016/j.ajpath.2022.08.007. PMID: 36150506
Treatment Algorithms for Systemic Sclerosis According to Experts.
Fernández-Codina A, Walker KM, Pope JE; Scleroderma Algorithm Group
Arthritis Rheumatol 2018 Nov;70(11):1820-1828. Epub 2018 Sep 17 doi: 10.1002/art.40560. PMID: 29781586
Recent Developments in the Classification, Evaluation, Pathophysiology, and Management of Scleroderma Renal Crisis.
Ghossein C, Varga J, Fenves AZ
Curr Rheumatol Rep 2016 Jan;18(1):5. doi: 10.1007/s11926-015-0551-y. PMID: 26711696
Renal endpoints in hypertension trials.
Christiansen H, Segura J, Ruilope LM
Clin Exp Hypertens 2004 Oct-Nov;26(7-8):721-6. doi: 10.1081/ceh-200032109. PMID: 15702626

Recent systematic reviews

Systemic Sclerosis Sine Scleroderma: A Time of Reappraisal.
Makris A, Panagiotopoulos A, Distler O, Sfikakis PP
J Rheumatol 2024 Nov 1;51(11):1060-1068. doi: 10.3899/jrheum.2023-1113. PMID: 38950948
Angiotensin-converting enzyme inhibitors prior to scleroderma renal crisis in systemic sclerosis: A systematic review and meta-analysis.
Xiong A, Cao Y, Xiang Q, Song Z, Zhang Y, Zhou S, Qiang Y, Chen H, Hu Z, Cui H, Luo J, Wang Y, Yang Y, Yang M, Shuai S
J Clin Pharm Ther 2022 Jun;47(6):722-731. Epub 2022 Mar 1 doi: 10.1111/jcpt.13621. PMID: 35233779
Improvement with time of vascular outcomes in systemic sclerosis: a systematic review and meta-analysis study.
Hughes M, Zanatta E, Sandler RD, Avouac J, Allanore Y
Rheumatology (Oxford) 2022 Jul 6;61(7):2755-2769. doi: 10.1093/rheumatology/keab850. PMID: 34791057
Update of EULAR recommendations for the treatment of systemic sclerosis.
Kowal-Bielecka O, Fransen J, Avouac J, Becker M, Kulak A, Allanore Y, Distler O, Clements P, Cutolo M, Czirjak L, Damjanov N, Del Galdo F, Denton CP, Distler JHW, Foeldvari I, Figelstone K, Frerix M, Furst DE, Guiducci S, Hunzelmann N, Khanna D, Matucci-Cerinic M, Herrick AL, van den Hoogen F, van Laar JM, Riemekasten G, Silver R, Smith V, Sulli A, Tarner I, Tyndall A, Welling J, Wigley F, Valentini G, Walker UA, Zulian F, Müller-Ladner U; EUSTAR Coauthors
Ann Rheum Dis 2017 Aug;76(8):1327-1339. Epub 2016 Nov 9 doi: 10.1136/annrheumdis-2016-209909. PMID: 27941129
Clinical relevance of antiphospholipid antibodies in systemic sclerosis: A systematic review and meta-analysis.
Merashli M, Alves J, Ames PRJ
Semin Arthritis Rheum 2017 Apr;46(5):615-624. Epub 2016 Oct 13 doi: 10.1016/j.semarthrit.2016.10.004. PMID: 27838012

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...